By Enzo Berardesca, Howard L. Maibach, Joachim W. Fluhr
The 1st entire resource to expertly learn each element of delicate dermis, this resource offers an updated evaluate of the overview, analysis, and remedy of this ordinarily encountered dermatological situation. that includes contributions from well-known global leaders during this zone of analysis, this advisor surveys the most recent medical reviews and pharmaceutical advancements to assist experts wrestle and handle the various complexities linked to delicate pores and skin.
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Extra resources for Sensitive Skin Syndrome (Dermatology: Clinical & Basic Science)
0 Hz range (NPIII or SAI), and Ruffini end organs producing a “buzzing” sensation in the 100 to 500 Hz range (NPII or SAII). Neurophysiological studies have by and large supported this model, but there is still some way to go to link the anatomy with perception (refer to Table 1 for a summary of the properties of these LTMs). There have been relatively few studies of tactile sensitivity on hairy skin, the cat being the animal of choice for most of these studies. 5 80 12 1 1 ,1 ,1 1 ,1 Abbreviations: CV, conduction velocity; LTM, low-threshold mechanoreceptor.
An interesting development in the understanding of the role of endocannabinoids in skin has been the observation that they can also activate VR1. Anandamide has been shown to activate VR1 (66,67) and this may explain the ability of anandamide to act as a vasodilator, although there is still some controversy over levels required to activate VR1 and its physiological relevance. THE CENTRAL PROJECTIONS The submodalities of skin-sensory receptors and nerves that convey information to the brain about mechanical, thermal, and painful stimulation of the skin are grouped into three different pathways in the spinal cord and project to different target areas in the brain.
Greenspan JD, Lamotte RH. Cutaneous mechanoreceptors of the hand: experimental studies and their implications for clinical testing of tactile sensation. J Hand Ther 1993; 6:75– 82. 5. Vallbo AB, Hagbarth K, Torebjork E & Wallin BG. Somatosensory, proprioceptive and sympathetic activity in human peripheral nerves. Physiol Rev 1979; 59:919– 957. 6. Willis WD, Coggeshall RE. Sensory Mechanisms of the Spinal Cord. 2nd ed. New York: Plenum Press, 1991. 7. von Bekesy G. Uber die Vibrationsempfindung [On the vibration sense].