By Bruce R. Smoller
Dermatopathology: The Basics will function a good and effective guide for the coed of dermatopathology, and as a realistic bench reference for the working towards diagnostician who wishes speedy entry to standards which are helpful in differentiating histologically comparable entities. The chapters encompass crucial bullet issues prepared in prepared outlines making an allowance for quick access and direct comparability among entities. the frilly pictorial documentation also will let the e-book to function an atlas of the commonest dermatologic disorders.
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I do not care a lot for the way the ebook is geared up, specially the index. for instance, should you have no idea what a sickness is termed (and new pathology citizens won't understand a minimum of half the stipulations defined during this publication) you've got a very tough time taking a look up the data by way of the surface adjustments. On a couple of get together i discovered myself flipping throughout the photos until eventually i discovered whatever like my specimen and after which move from there to get the prognosis. nonetheless, this publication is simple to learn and the authors take time to give an explanation for how you can differentiate x from y they usually even offer you an inventory of differentials for the condition.
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Additional resources for Dermatopathology: The Basics
16) Fig. , corresponding to the site of collagen VII • Tissue must be frozen – cannot be exposed to formalin or direct immunofluorescence procedure will not work • To preserve antigenicity, the specimen can be placed on a saline-soaked gauze, not drenched, for a few hours or in Michel’s fixative for up to a week “Dermatitis” and “Rash” • A punch biopsy is the procedure of choice Inflammatory Processes 53 • This allows for adequate interpretation of epidermal changes (spongiotic or interface), as well as the pattern of inflammatory infiltrate (superficial and/or deep, perivascular, periappendageal or diffuse) and characteristic inflammatory cells (lymphocytes, plasma cells, and/or eosinophils) (Fig.
Ideally, there will be normal tissue below the neoplasm Presumed Neoplastic Processes 39 – If the lesion is melanoma, then a depth measurement is needed, so there must be normal tissue beneath the tumor (Fig. 1) – Depth measurements on re-excision specimens are notoriously unreliable – first chance is the best for accurate data – Electrodessication, curettage, and very thin shave biopsies may obscure this information Are the Margins Important? • Elliptical excisions (oriented) provide the best way to assess margins with routine histopathology – Mohs surgery may provide more complete information, but is not readily available for all cases • Deeper shave biopsies (saucerization) may also permit evaluation of surgical margins in some cases (Fig.
This is a crucial point prior to doing the biopsy. • If melanoma is in the differential diagnosis: – Complete visualization of the basal layer is crucial – There needs to be enough dermis to evaluate for maturation Fig. 1 Lesions that are clinically worrisome for melanoma need to be biopsied deep enough to allow for measurement of depth. Ideally, there will be normal tissue below the neoplasm Presumed Neoplastic Processes 39 – If the lesion is melanoma, then a depth measurement is needed, so there must be normal tissue beneath the tumor (Fig.