Adverse Cutaneous Drug Reactions to Cardiovascular Drugs by Esen Özkaya, Kurtuluş Didem Yazganoğlu

By Esen Özkaya, Kurtuluş Didem Yazganoğlu

Adverse cutaneous drug reactions (ACDR) are one of the such a lot common occasions in sufferers receiving drug treatment. Cardiovascular (CV) medications are a massive staff of gear with power danger of constructing ACDR in particular in aged as advertising and marketing of extra new medicinal drugs and their prescription proceed to extend. even though, like with so much different medications the precise prevalence of cutaneous unwanted side effects from CV medicines is hard to estimate as a result of sporadic reporting. in addition, a competent designation of a definite drug because the reason for a undeniable kind of response can infrequently be made. except the well known angioedema/urticaria from ACE inhibitors, lichen planus / lichenoid response from beta adrenergic blockers and photosensitivity from thiazid diuretics, ACDR from CV medicinal drugs could be obvious in a large spectrum extending to infrequent yet life-threatening stipulations akin to erythroderma, Stevens-Johnson syndrome, poisonous epidermal necrolysis or drug allergic reaction syndrome. during this complete assessment, the mentioned sorts of ACDR to CV medicines can be mentioned in keeping with drug category and the kind of dermatologic response with precise emphasize on cross-reactions and the function of patch trying out in diagnosis.

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16 Symmetrical erythema on the groins and the upper inner surface of the thighs in a V-shaped pattern in Baboon syndrome 1 General Aspects of Adverse Cutaneous Drug Reactions Characteristic Features of Adverse Cutaneous Drug Reactions 13 Fig. 17 Symmetrical lesions on major flexural and intertriginous areas such as the axillae and antecubital fossae in SDRIFE (symmetrical drug-related intertriginous and flexural exanthema) other intertriginous/flexural fold, (4) symmetry of affected areas, and (5) absence of systemic symptoms and signs [12].

Histopathology shows subcorneal epidermal pustules, mild spongiosis, few necrotic keratinocytes, and superficial dermal edema with a lymphocytic infiltration occasionally including eosinophils [4]. Beta-lactam antibiotics such as amoxicillin and ampicillin, hydroxychloroquine, sulfonamides, terbinafine, and the cardiovascular drug diltiazem are the main inducers of pustular drug eruption/AGEP [32]. The reaction usually resolves within 2 weeks after stopping the causative drug, and in severe cases with treatment of systemic corticosteroids.

Cardiovascular drugs such as beta-blockers are also among the inducers of this type of reaction. Other Skin Reactions Pruritus and flushing are other frequently reported adverse reactions of drug therapy. Cardiovascular drugs including statins have been reported among the main inducers of drug-induced pruritus [74]. Flushing may occur with vasodilators and CCBs. Xerosis is a common side effect of lipid-lowering drugs. Peripheral edema is frequently associated with the use of adrenergic neuron blockers (reserpine), CCBs, and vasodilators.

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