Advances in Structural Biology, Volume 6 (Advances in by S.K. Malhotra

By S.K. Malhotra

In line with the large pursuits set for the serial booklet of Advances in Structural Biology, quantity 6 comprises exhaustive articles from specialists in varied parts of biomedical examine. the typical thread one of the a number of articles is their relevance to the purposes of telephone biology to human well-being.

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In the research arena, Oncor, Inc. (Gaithersburg, MD) has received FDA approval for a DNA probe to detect amplification of the H E R - 2 ~ n e u oncogene. As Chang and Mark (1997) pointed out, since today's research may be tomorrow's clinical procedures, it behooves all physicians, scientists, and others interested in laboratory genetics to closely monitor developments in this rapidly evolving field. ACKNOWLEDGMENTS The author thanks Dr. Herman Wyandt, Ms. Anne Richardson, and Dr. Roger Mark for reading the manuscript.

Conventional cytogenetics has the capability of distinguishing female (XX) cells and male (XY) cells in metaphase spreads. FISH can distinguish between host and donor cells in both interphase and metaphase cells. By detecting the ratio of XX to XY cells using FISH with the X chromosome and Y chromosome probes in a post-BMT sample, the degree of success for engraftment can be assessed and disease recurrence can be better predicted. Applications for Cancer Specimens with Low Mitotic Index, Suboptimal Preparations, Nondividing and Terminally Differentiated Cells Conventional cytogenetics of cancer has been hampered by the requirement that there be a sufficient number of dividing cells of adequate quality for karyotypic analysis.

Oral Surg. Oral Medi. Oral Pathol. 1996b, 82, 187-192. ; Braun, L. Ann. Clin. Lab. Sci. 1996c, 26, 147-153. ; Seifer, D. ;. H. Clin. Pediatr 1996d, 35, 2, 62-66. C. Cytobios 1996e, 87, 117-126. ; Beauregard, U; Greenstein, R. Cytobios 19961, 88, 43-52. A. Ann. Clin. Lab. Sci. 1997a, 27, 47-56. B. Ann. Clin. Lab. Sci. 1997b, 27, 293-298. C. CancerGenet. Cytogenet. 1997c, 96, 1-6. ; Zolnierz, K. Cam'erGenet. Cytogenet. 1997d, 100, 1-5. C. Ann. Clin. Lab. Sci. 1997e, 27, 224-229. ; Bland, K. I. Pathobiology 1997f, 65, 184--189.

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