Advances in Cancer Research, Vol. 49 by George Klein (ed.), Sidney Weinhouse (ed.)

By George Klein (ed.), Sidney Weinhouse (ed.)

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The c-fos protein has 380 amino acids, which is remarkably similar to the size of the v-fos protein (381amino acids). 7 . In the first 332 amino acids, the v-fos and mouse c-fos proteins differ at only five residues, whereas the remaining 48 amino acids of the c-fos protein are encoded in a different reading frame from that in the v-fos protein. Thus, the v-fos and c-fos proteins, though largely similar, have different carboxyl termini (Fig. 3A). 8. , 1984) (Fig. 4). 9. , 1983). 10. The putative parents of FBJ-MSV (namely, FBJ-MLV and c-fos gene) share a 5-nucleotide sequence at the 5’ end and 10 of 11nucleotides at the 3’ end of the v-fos region.

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