Advances in Cancer Research, Vol. 49 by George Klein (ed.), Sidney Weinhouse (ed.)

By George Klein (ed.), Sidney Weinhouse (ed.)

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The c-fos protein has 380 amino acids, which is remarkably similar to the size of the v-fos protein (381amino acids). 7 . In the first 332 amino acids, the v-fos and mouse c-fos proteins differ at only five residues, whereas the remaining 48 amino acids of the c-fos protein are encoded in a different reading frame from that in the v-fos protein. Thus, the v-fos and c-fos proteins, though largely similar, have different carboxyl termini (Fig. 3A). 8. , 1984) (Fig. 4). 9. , 1983). 10. The putative parents of FBJ-MSV (namely, FBJ-MLV and c-fos gene) share a 5-nucleotide sequence at the 5’ end and 10 of 11nucleotides at the 3’ end of the v-fos region.

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Virol. 557-565. , and Curran, T. Nature (London)312,716720. Nadal-Girard, B. (1978). Cell 15, 855-864. , and Ikawa, Y. (1985). Nature (London)318,73-75. , and Weber, K. (1984). In “Cancer Cells” (A. J. Levine, G. F. Wande Woude, W. C. Topp, and J. D. ),Vol. 1, pp. 191-200. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. , and Holtzer, H. (1977). Cell 11, 891-899. Palmieri, S. J . Virol. 58, 134-141. , and Graf, T. (1982). Virology 123, 296-311. , and Graf, T. (1983). EMBO J . 2,2385-2389.

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